{"metadata":{"accession":"Q2G1E1","id":"HPTR_STAA8","source_organism":{"taxId":"93061","scientificName":"Staphylococcus aureus (strain NCTC 8325 / PS 47)","fullName":"Staphylococcus aureus (strain NCTC 8325 / PS 47)"},"name":"Transcriptional regulatory protein HptR","description":["Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources (PubMed:25644013). Activates uhpT expression to facilitate glucose-6-phosphate/G6P utilization by directly binding to its promoter (PubMed:26711125). Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility (PubMed:30540769)"],"length":252,"sequence":"MFKVVICDDERIIREGLKQIIPWGDYHFNTIYTAKDGVEALSLIQQHQPELVITDIRMPRKNGVDLLNDIAHLDCNVIILSSYDDFEYMKAGIQHHVLDYLLKPVDHAQLEVILGRLVRTLLEQQSQNGRSLASCHDAFQPLLKVEYDDYYVNQIVDQIKQSYQTKVTVSDLIQHIDVSESYAMRTFKDHVGITIVDYLNRYRILQSLQLLDRHYKHYEIADKVGFSEYKMFSYHFKKYLQMSPSDYCKQAK","proteome":"UP000008816","gene":"hptR","go_terms":[{"identifier":"GO:0000160","name":"phosphorelay signal transduction system","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"325fead2059cae88badcae2f43b34da8fb2986b9","counters":{"domain_architectures":23395,"entries":17,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"smart":2,"profile":2,"pfam":2,"cdd":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":23395}}}