{"metadata":{"accession":"Q2ET08","id":"OSPF_SHIDY","source_organism":{"taxId":"622","scientificName":"Shigella dysenteriae","fullName":"Shigella dysenteriae"},"name":"Phosphothreonine lyase OspF","description":["Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of pro-inflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host (By similarity)"],"length":170,"sequence":"PQMLSANERLKNNFNILYNQIRQYPAYYFKVASNVPTYSDICQFFSVMYQGFQIVNHSGDVFIHACRENPQSKGDFVGDKFHISIAREQVPLAFQILSGLLFSEDSPIDKWKITDMNRVSQQSRVGIGAQFTLYVKSDQECSQYSALLLHKIRQFIMCLESNLLRSKIAP","proteome":null,"gene":"ospF","go_terms":null,"protein_evidence":3,"source_database":"reviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8235289369967b6b8159705328d07e9d345661c7","counters":{"domain_architectures":330,"entries":6,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ncbifam":1,"pfam":1,"prints":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":330}}}