{"metadata":{"accession":"Q183T6","id":"Q183T6_CLOD6","source_organism":{"taxId":"272563","scientificName":"Clostridioides difficile (strain 630)","fullName":"Clostridioides difficile (strain 630)"},"name":"D-alanine--D-alanyl carrier protein ligase","description":["Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall"],"length":504,"sequence":"MKIIEGIKKYSNTDRTALMCNGDKLSYKDLNEYSDAISVFLKDVYKEEDTPIVIYGNKENMIMACMIGALKSGRAYVPLDISFPIDRVFEVTKEIKPKVLFNFSDERNFGDINVIDMDKLNYIINEYQGKSLDKENWVKDDENAYILFTSGSTGKPKGVQISSNNLDSFSDWISPYLNIDGSEKVIMNQPAYSFDLSVTTIYPGLIHGATLFSISKDVLADYKELFRQFSISDIAVWVSTPSFAGVCITEKEFNSKMLPNLESMIFIGEALSKNLTKELMSRFPNTRIINGYGPTEATVGVSVNDMTQKAIDDEKSLPVGYPMSNCKIKILDEDGNELKENEKGEIIIIGPSVSKGYFNNKEKTDEVFFYDEIDGVKWRAYKTGDMGYLLDGNIYYCGRKDFQIKLNGFRIEIEDIENNLRKVHNVKNAVVLPVYKDEKIAYLKGIVELNEKNDLSNIKNGMIIKKELGKYIPSYMIPRNISIISEFPTNINGKIDRKKLMEEI","proteome":null,"gene":"dltA","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0047473","name":"D-alanine [D-alanyl carrier protein] ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070395","name":"lipoteichoic acid biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ba6ba0b0e99fc7c9ffcc323888fecbac8c6c4763","counters":{"domain_architectures":241937,"entries":19,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":1,"ssf":1,"pfam":2,"ncbifam":2,"hamap":1,"panther":1,"prosite":1,"interpro":8},"proteome":0,"taxonomy":1,"similar_proteins":241937}}}