{"metadata":{"accession":"Q14376","id":"GALE_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"UDP-glucose 4-epimerase","description":["Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids"],"length":348,"sequence":"MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA","proteome":"UP000005640","gene":"GALE","go_terms":[{"identifier":"GO:0003978","name":"UDP-glucose 4-epimerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006012","name":"galactose metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3ce5b4f1d430f3efd867f66a5de417b23394787f","counters":{"domain_architectures":84379,"entries":12,"isoforms":2,"proteomes":1,"sets":2,"structures":11,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"cathgene3d":2,"pfam":1,"panther":1,"ncbifam":2,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":84379}}}