{"metadata":{"accession":"Q0IHT3","id":"CRTC3_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"CREB-regulated transcription coactivator 3","description":["Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation. Enhances the interaction of creb1 with taf4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity)"],"length":637,"sequence":"MAATPAASGSNPRKFSEKIALHNQKQAEETRAFDELMSDLTVSRVQFQKLQQLRLAQSRAQYYGGSLPNVNQISSSPTDFQPSFHPTDNIRGMRHHGLVERVSRNRLHSSHHRPIEKHGRQCDSSPYGSVYLSPPPDNNWRRTNSDSALHTSASSTKSQDPFMGGAQAMLRAPKPPQRNTSLQDGEIDNFGEVFSFPNAMTEENMLNVTKPLPKQIWEAQKVQCITSRPRSCEVPNIKVFPSSDSNASLSHFQGSLNTGGSLPDLTNLHFPSPLPTPLDPDDTAYANISAENSSGLPAAMTHLGISGSPGMQNTRSNPSIQATMNNNSLASNVNSHTPPGRNNPALHPSLRLSSLSNPSLPTSALGTSPRRRHTPVSPLTLTPGSESNRSISNQFSPTSPMNMPPNSQGVSMDRSPLSLPPLEPPPPYPLYSDQPQPHLHHTQQQMHESLDSQNYQPPSPVPCPPLDLNLANSSLSGFFGDSFFDQQQPTKQGKYLWQQQEQYDMFGSPSSSLPNTNAFFDPNMNLQYSQASLMGLGGSHGSLQDSFHLRPNYLYSNCGGSVPNIILTDDSSNSLSKDISNAVAGVSELGFDADNTFQLDDELKLGPLSLDGLSMLSDPDMVLPDPSIEDSFRSDKL","proteome":"UP000008143","gene":"crtc3","go_terms":[{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0008140","name":"cAMP response element binding protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051289","name":"protein homotetramerization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3148b27c77231e098c12fc5f0c5af7f632beff08","counters":{"domain_architectures":2107,"entries":8,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"pfam":3,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":2107}}}