{"metadata":{"accession":"P9WNK5","id":"ESXB_MYCTU","source_organism":{"taxId":"83332","scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","fullName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)"},"name":"ESAT-6-like protein EsxB","description":["A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca(2+) release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481)"],"length":100,"sequence":"MAEMKTDAATLAQEAGNFERISGDLKTQIDQVESTAGSLQGQWRGAAGTAAQAAVVRFQEAANKQKQELDEISTNIRQAGVQYSRADEEQQQALSSQMGF","proteome":"UP000001584","gene":"esxB","go_terms":null,"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"88fb9c5a15985d92eabebad18589dfb60045a461","counters":{"domain_architectures":18554,"entries":6,"isoforms":0,"proteomes":1,"sets":1,"structures":2,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"ncbifam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":18554}}}