{"metadata":{"accession":"P61611","id":"LEXA_LEPIC","source_organism":{"taxId":"267671","scientificName":"Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)","fullName":"Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)"},"name":"LexA repressor","description":["Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair"],"length":203,"sequence":"MKDLTDKQQAVLAFITAIIKERGFPPTIREIGDEFGITAKGAYDHLKAIEKKGYLKTAKNQSRAIELIRQSPMESLPVQATSIPVIGQVAAGLPIFAEENIESYIPVPDEMAKGNVPMYALRVQGDSMIEVGINDGDIAIIEKRDIARNGEIVVALIEDEATLKVYYKEQDQIRLEARNPKYKPIKTKKATVMGKLIGLYRIY","proteome":null,"gene":"lexA","go_terms":[{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009432","name":"SOS response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045892","name":"negative regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"80ebd7e7a187ff1e5bf9b0d007a9803b2e453c54","counters":{"domain_architectures":20379,"entries":20,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"ssf":2,"cdd":1,"ncbifam":1,"panther":1,"hamap":1,"prints":1,"interpro":9},"proteome":0,"taxonomy":1,"similar_proteins":20379}}}