{"metadata":{"accession":"P61138","id":"SYUA_ATEGE","source_organism":{"taxId":"9509","scientificName":"Ateles geoffroyi","fullName":"Ateles geoffroyi (Black-handed spider monkey)"},"name":"Alpha-synuclein","description":["Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity)"],"length":140,"sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTSVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDHSGKSEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","proteome":null,"gene":"SNCA","go_terms":[{"identifier":"GO:0014059","name":"regulation of dopamine secretion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ba377935bbbad4e8c0f939864858b21a58ebc159","counters":{"domain_architectures":3377,"entries":8,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"panther":1,"pfam":1,"prints":2,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":3377}}}