{"metadata":{"accession":"P56273","id":"MDM2_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"E3 ubiquitin-protein ligase Mdm2","description":["E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome"],"length":473,"sequence":"MNLTSTTNCLENNHISTSDQEKLVQPTPLLLSLLKSAGAQKETFTMKEVIYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEPRRLYAMISRNLVSANVKESSEDIFGNVCCFPDKQSSQKEKLQELPDKLIAPASDSKPCNLSQRKSSNETEEISSVDHPAEQQRKRHKSDSFSLTFDESLSWWVISGLRCDRNSSESTDSSSNSDPERHSTNDNSEHDSDQFSVEFEVESVCSDDYSPSGDEHGVSEEEEINDEVYQVTIYETEESETDSFDVDTEISEADYWKCPECGEVNPPLPSYCPRCWTVRKDWLPEQRRKEPPPSKRKLLEIEEDEGFDVPDCKKSKLTSSQDTNVDKKEAENIQNSESQETEDCSQPSTSGSIASCSQEVTKEDSSKESMESSLPLTSIDPCVICQTRPKNGCIVHGRTGHLMACYTCAKKLKKRNKPCPVCREPIQMIVLTYFS","proteome":"UP000186698","gene":"mdm2","go_terms":[{"identifier":"GO:0042802","name":"identical protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0061630","name":"ubiquitin protein ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043066","name":"negative regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0051726","name":"regulation of cell cycle","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"37973506204de2200c471ef6d28d09548fc718e5","counters":{"domain_architectures":854,"entries":27,"isoforms":0,"proteomes":1,"sets":6,"structures":12,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"cdd":2,"profile":3,"pfam":3,"pirsf":2,"panther":1,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":854}}}