{"metadata":{"accession":"P50528","id":"PLO1_SCHPO","source_organism":{"taxId":"284812","scientificName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","fullName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)"},"name":"Serine/threonine-protein kinase plo1","description":["Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle (PubMed:12615979, PubMed:12815070, PubMed:22375062, PubMed:25533956, PubMed:7744248). During prometaphase and metaphase, phosphorylates the kinetochore component dam1 of unaligned or unattached chromosomes to promote mitotic sister chromatid biorientation (PubMed:22375062). During meiosis I and together with moa1, required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division (PubMed:12615979, PubMed:12815070, PubMed:7744248)"],"length":683,"sequence":"MASVAIKEPKTAITPKKKSKASRLCFTPPTNLHNNKKNIFYTRYDCIGEGGFARCFRVKDNYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSHPNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLKLGNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEFFHTGYMASTLPDEILHSMPIWPSSQSKSSFQRNLDFVASASGVGFGNSAGVEKNKPYALRTDEVDNDRILPSVLSPRDRVNPVMKIGPETKPVPSKLSTALHAARKSTDGSLGSRVKVLREESQSFVPTKSAVTEQVEPIQLIRSLSANTVSRLSKVGNMKSDIWISVKKTALKIGMALEAHTHALTSEDADSEPVLFITKWVDYSNKYGLGYQLSDESVGVHFNDDTSLLFSADEEVVEYALHPKDTEIKPYIYPASKVPESIRSKLQLLKHFKSYMGQNLSKAVQDESFEKPKNSTSNTMLFMQHYLRTRQAIMFRLSNGIFQFNFLDHRKVVISSTARKIIVLDKERERVELPLQEASAFSEDLRSRLKYIRETLESWASKMEVS","proteome":"UP000002485","gene":"plo1","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"784705cd30605492ec4d83551df2abc00d0df07d","counters":{"domain_architectures":5262,"entries":23,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":2,"pfam":2,"smart":1,"cdd":3,"ssf":2,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":5262}}}