{"metadata":{"accession":"P40946","id":"ARF6_DROME","source_organism":{"taxId":"7227","scientificName":"Drosophila melanogaster","fullName":"Drosophila melanogaster (Fruit fly)"},"name":"ADP-ribosylation factor 6","description":["GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis (PubMed:21976699). Required for normal ethanol-induced tolerance and preference (PubMed:28607459). Probably after Efa6-mediated activation, counteracts ethanol-induced sedation (PubMed:28607459)"],"length":175,"sequence":"MGKLLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARTELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLSEGLIWLTSNHKL","proteome":"UP000000803","gene":"Arf6","go_terms":[{"identifier":"GO:0003924","name":"GTPase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005525","name":"GTP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d6bc1331c4b416e231f52943c4822a3a2b702855","counters":{"domain_architectures":72767,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":3,"pfam":1,"cathgene3d":1,"cdd":1,"profile":1,"ssf":1,"ncbifam":1,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":72767}}}