{"metadata":{"accession":"P0DXB6","id":"CGLR_MICDL","source_organism":{"taxId":"69319","scientificName":"Microplitis demolitor","fullName":"Microplitis demolitor (Parasitoid wasp)"},"name":"Cyclic GMP-AMP synthase-like receptor","description":["Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)"],"length":520,"sequence":"MNGDEQNKKKLRSDAMFGKINQFVTLQKDETAKYNSLFTKVTESIVSILKEKDEVFKKYYRNTMYAGSFYKQTRVGQPKEFDLNLILCLPDIDSVKIEKGRPGFAKIKFDERKISSVWTEHKVLNKWLDSEGYLDNGKLRGWFEGMVKKSLNPSEKNSNKFRIYSKDSSSPLCEAEIKKSGPAFTLIVNDGSMEFAVDLVPVLEFSQSPPLSNFEKLKEPWHLVPKPLKNGDVPNQNWRYCFYHYEKEMLKKNGKVKPIIRHIKKLRDTQNWSILASYYIETLFFHVLSKNDFDQNESQTRLLVYMLKELSKAFKSGLLNYFWDKTFNLFGELTEDQIVGVQNRLDKIIKEIEADPTTMTQYFLTKEEQKKLKEIEEKEKTQPKKEVNVDKTNGLSSTFPLIRETKSEKNKKIIQESENRETSKNEIKALKEMVLSLKAEFKDFKNSIKQKPIDQTPETEGTDEKEMKKLLLLLINEVKQLKLNVGRLETKIDQTNEQIKNIKSQSTFFDVMETGVPLLN","proteome":null,"gene":"cGLR","go_terms":null,"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3aebc1c0b41b5199648bfafd6f9a02a39a1a71ac","counters":{"domain_architectures":7552,"entries":9,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":1,"pfam":2,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":7552}}}