"accession"	"counters"	"description"	"gene"	"go_terms"	"id"	"ida_accession"	"in_alphafold"	"in_bfvd"	"is_fragment"	"length"	"name"	"protein_evidence"	"proteome"	"sequence"	"source_database"	"source_organism"
"P0AEJ4"	"{'domain_architectures': 119765, 'entries': 26, 'isoforms': 0, 'proteomes': 1, 'sets': 5, 'structures': 11, 'taxa': 1, 'dbEntries': {'pfam': 3, 'cathgene3d': 2, 'profile': 2, 'smart': 3, 'cdd': 3, 'ssf': 2, 'ncbifam': 1, 'panther': 1, 'prints': 1, 'interpro': 8}, 'proteome': 1, 'taxonomy': 1, 'similar_proteins': 119765}"	"['Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:2997120, PubMed:3536870). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (PubMed:1323560, PubMed:2277041, PubMed:2558046, PubMed:2656684, PubMed:2668281, PubMed:2668953, PubMed:2674113). Also dephosphorylates OmpR in the presence of ATP (PubMed:1323560, PubMed:2277041, PubMed:2558046, PubMed:2668281). The cytoplasmic dimerization domain (CDD) forms an osmosensitive core; increasing osmolarity stabilizes this segment (possibly by its contraction), enhancing the autophosphorylation rate and consequently, downstream phosphotransfer to OmpR and signaling (PubMed:22543870, PubMed:28256224). Autophosphorylation is greater when full-length EnvZ is reconstituted in a lipid environment, lipid-mediated allostery impacts the kinase function of EnvZ (PubMed:28256224). Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation, and suggests that EnvZ senses cytoplasmic acidic pH (PubMed:29138484)']"	"envZ"	"[{'identifier': 'GO:0007165', 'name': 'signal transduction', 'category': {'code': 'P', 'name': 'biological_process'}}, {'identifier': 'GO:0016020', 'name': 'membrane', 'category': {'code': 'C', 'name': 'cellular_component'}}, {'identifier': 'GO:0000155', 'name': 'phosphorelay sensor kinase activity', 'category': {'code': 'F', 'name': 'molecular_function'}}, {'identifier': 'GO:0016772', 'name': 'transferase activity, transferring phosphorus-containing groups', 'category': {'code': 'F', 'name': 'molecular_function'}}, {'identifier': 'GO:0016310', 'name': 'phosphorylation', 'category': {'code': 'P', 'name': 'biological_process'}}]"	"ENVZ_ECOLI"	"ed5ddfc4745162f183328622157829c334589c3b"	True	False	False	450	"Sensor histidine kinase EnvZ"	1	"UP000000625"	"MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG"	"reviewed"	"{'taxId': '83333', 'scientificName': 'Escherichia coli (strain K12)', 'fullName': 'Escherichia coli (strain K12)'}"