{"metadata":{"accession":"P0ACZ4","id":"EVGA_ECOLI","source_organism":{"taxId":"83333","scientificName":"Escherichia coli (strain K12)","fullName":"Escherichia coli (strain K12)"},"name":"DNA-binding transcriptional activator EvgA","description":["Member of the two-component regulatory system EvgS/EvgA (PubMed:10825546, PubMed:10923791, PubMed:9535079). The EvgS/EvgA system is involved in regulating the expression of glutamate-dependent acid resistance genes, acting in concert with transcription factors YdeO and GadE (PubMed:12694615, PubMed:15489450, PubMed:17998538). Regulates the expression of emrKY and safA-ydeO operons, gadE, yfdX and probably ydeP (PubMed:10923791, PubMed:11157960, PubMed:12694615, PubMed:15489450, PubMed:17998538). Binds directly to an 18 bp consensus sequence similar to 5'-AGCCTACACCTGTAAGAA-3' in the promoter region of safA/b1500 and other target genes, including its own operon, evgAS (PubMed:12694615, PubMed:15489450, PubMed:17998538). Also may control expression of multi-drug transporter mdtEF and other multi-drug efflux systems (PubMed:11157960, PubMed:11914367). Overexpression can confer resistance to antibiotics such as beta-lactams, probably as a result of up-regulation of multi-drug efflux systems (PubMed:12951338)"],"length":204,"sequence":"MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG","proteome":"UP000000625","gene":"evgA","go_terms":[{"identifier":"GO:0000160","name":"phosphorelay signal transduction system","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bf2a74b77e142e5501cae2a7fdcb5764135340de","counters":{"domain_architectures":202586,"entries":24,"isoforms":0,"proteomes":1,"sets":4,"structures":2,"taxa":1,"dbEntries":{"smart":2,"ssf":2,"cathgene3d":2,"profile":2,"pfam":2,"cdd":2,"ncbifam":1,"panther":1,"prints":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":202586}}}