{"metadata":{"accession":"P06132","id":"DCUP_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"Uroporphyrinogen decarboxylase","description":["Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:18004775, PubMed:21668429). Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (PubMed:11069625, PubMed:11719352, PubMed:14633982, PubMed:21668429). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:12071824)"],"length":367,"sequence":"MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN","proteome":"UP000005640","gene":"UROD","go_terms":[{"identifier":"GO:0004853","name":"uroporphyrinogen decarboxylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006779","name":"porphyrin-containing compound biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d6e8a475ff3b2424583204beff75cdb65c82925d","counters":{"domain_architectures":35055,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":19,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"cdd":1,"panther":1,"hamap":1,"ncbifam":1,"prosite":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":35055}}}