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{
    "metadata": {
        "accession": "O83245",
        "id": "GRPE_TREPA",
        "source_organism": {
            "taxId": "243276",
            "scientificName": "Treponema pallidum (strain DSM 117211 / Nichols)",
            "fullName": "Treponema pallidum (strain DSM 117211 / Nichols)"
        },
        "name": "Protein GrpE",
        "description": [
            "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding"
        ],
        "length": 220,
        "sequence": "MCGGDVQGQGVASGCDEALERADSLRASDPVPVESGEGSVPGEHSQELETGASEETLRERVNVLQEQYLRKAADLENYRKRALRERQEAVEHAYAALLADIVAVLDDFDRAIEAADHASSTEVEASSAFREGVLMIRKQLSSVLETKYGLEYYPVLGERFDPNLHEALSMSPSASVHEKIVGAELQKGYRVRNRILRHAKVMVLTPEEQTEPDRGDGPSE",
        "proteome": "UP000000811",
        "gene": "grpE",
        "go_terms": [
            {
                "identifier": "GO:0000774",
                "name": "adenyl-nucleotide exchange factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0042803",
                "name": "protein homodimerization activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0051087",
                "name": "protein-folding chaperone binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006457",
                "name": "protein folding",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "ida_accession": "bcfacd3ac840c2030716357b736a826603778042",
        "counters": {
            "domain_architectures": 27015,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 1,
                "hamap": 1,
                "panther": 1,
                "pfam": 1,
                "prosite": 1,
                "prints": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 27015
        }
    }
}