{"metadata":{"accession":"N9F3Q8","id":"N9F3Q8_ACIHA","source_organism":{"taxId":"1217659","scientificName":"Acinetobacter haemolyticus CIP 64.3 = MTCC 9819","fullName":"Acinetobacter haemolyticus CIP 64.3 = MTCC 9819"},"name":"Siroheme synthase","description":["Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme"],"length":458,"sequence":"MEIFPISLKLQQQRCLIVGGGHIAYRKANLLVKAGAIVDVIAPEIEPELTALVEKSAGQCIYKPFSEDILATPYRLIIAATDQPVVNKTVFEQCEQRNLLVNSVDDIPHCRFMVPAIIDRSPLVISVASNGASPVLSRQLRTQIETIVPHGMGRLAEFSGKWRKQVKEKITNPDERRIFWENLYASPLKEQVFNDNIDVANDLIQQALSEWIAPKGEVYLVGAGPGDPELLTLKALRLMQQADVVIYDRLVSAPILELCRRDAEKIYVGKARSNHSVPQDGINALLVEYAQKGRRVCRLKGGDPFIFGRGGEEIQELVEANVTFQVVPGITAASGCSAYAGIPLTHRDYAQSVRFLTGHLKEGSPELPWNELVYENQTLVLYMGLVGLERICEQLIAHGQRPTMPVALISKGTTPEQKVVVGTLADIATKVSEHQIVAPTLTIIGEVVSLREQLKWHE","proteome":"UP000017667","gene":"cysG","go_terms":[{"identifier":"GO:0006779","name":"porphyrin-containing compound biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019354","name":"siroheme biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004851","name":"uroporphyrin-III C-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043115","name":"precorrin-2 dehydrogenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051266","name":"sirohydrochlorin ferrochelatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051287","name":"NAD binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009236","name":"cobalamin biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b21b7e1a493f91cba0191d0d80577af8157ffeb2","counters":{"domain_architectures":2196,"entries":33,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"cathgene3d":5,"pfam":3,"cdd":1,"pirsf":1,"hamap":1,"ncbifam":4,"panther":1,"prosite":2,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":2196}}}