{"metadata":{"accession":"N6TEL7","id":"N6TEL7_DENPD","source_organism":{"taxId":"77166","scientificName":"Dendroctonus ponderosae","fullName":"Dendroctonus ponderosae (Mountain pine beetle)"},"name":"Reticulocalbin-3","description":["Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion"],"length":338,"sequence":"MRVTNIIFNWLTGYVIVLCSMTCWGAVMHKNFHSHDTLNSKSDEGKHATNREEYQAHMNSDEHRTNFDHEAILGSAKISEEFDALPPEQSKERLQALLNVMDTSRDKFIDRSELIQWIVHSFQMLSAEEANEKFDETDENDDKHISWNEYILESYGSEELSLQSNWADSDENIRIEFEQDQELFRAVDANNDGLLNRQEFSKFTNPEEHQDLSALLLKQILRSKDTDNDDALNFKEFLSEKGSQMSKEALISQKDEFDEYDMNKDGKLTGDEIIYWMFPQNEKIAEEETTHLFAQCDDNHDDLLSFDEILDHHEIFVGSEATNYGEHLHNIHEFTDEL","proteome":"UP000019118","gene":"109538559","go_terms":[{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"358b8ce5888a1598d09f2b89703ac5f177dde488","counters":{"domain_architectures":4556,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"profile":1,"smart":1,"pfam":2,"panther":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4556}}}