{"metadata":{"accession":"M9U8Y6","id":"M9U8Y6_SACIS","source_organism":{"taxId":"1241935","scientificName":"Saccharolobus islandicus LAL14/1","fullName":"Saccharolobus islandicus LAL14/1"},"name":"Diphthine synthase","description":["S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis"],"length":257,"sequence":"MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEADRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSERAMTANEALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKWMLMS","proteome":null,"gene":"dphB","go_terms":[{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004164","name":"diphthine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017183","name":"protein histidyl modification to diphthamide","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c6fc4066a6a3d3c96c9a871fe22501df278bed0f","counters":{"domain_architectures":80154,"entries":14,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":1,"cdd":1,"ssf":1,"hamap":1,"ncbifam":1,"pirsf":1,"panther":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":80154}}}