{"metadata":{"accession":"M3ZJ92","id":"M3ZJ92_XIPMA","source_organism":{"taxId":"8083","scientificName":"Xiphophorus maculatus","fullName":"Xiphophorus maculatus (Southern platyfish)"},"name":"Inositol 1,4,5-trisphosphate receptor","description":["Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity","Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium"],"length":2694,"sequence":"MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPDAGDLSNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGGNTDTVLLNKLHHAADLEKKQNDSENKKLLGTVIQYGHVIQLLHLKSNKYLTVNKRLPALLEKNAMRVMLDTAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASTHQLVDNPGCNEVNSVNCSTSWKIVLFMKWSDNQERVLKGGDVVRLFHAEQEKFLTCDDHRKKQYVFLRTTGRQSATSATSSKALWEIEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAELDSEQDPLRARLKIVQDKVLYTLISVPDGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNQPIDKEEEKPVMLRIGTSAYKEDKEAFAIVPVSPAEVRDLDFANDASKVLASIAGKLEKGTITQNERRAVTKLLEDLVFFVVDIPNNGQDVLEIMVNKPNRERQKLMREQNILKQIFKLLQAPFTDSGDGPMLRLEELADQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFRFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICTAVLDPANADILIETKLVLSRFEIEGSQLGENSVEVEEDEEEVWLFWNNSDKEMRSKSVREMAQDAKEGQKEDKEVISYYRYQLNLFARMCLDRQYLAINKISIQLDVDLILRCMSDEDLPFDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSKISINDYDNDGTTKDNIKERFWQTMEFVENYLRDVVCQNFPFADKEKNKLTSEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVSTVFPFTKLEKGDGGRGSNVMRSIHGVGELMSQVVLRGGGFLPINTNSDSNGDTVKTQIEPEKQDILVMDTKLKIIEILQFILNVRLDYRISCLLSIFKREFDESTSQNELSISGSVEGPNNIPGALDFENIEEQAEAIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHEYPPLVSRALHLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKEDLDKLRSIVEKSELWVYKRQGPDEGLDGGEGMPAEPEPQKAESASSKNYRVIKEVLLRLSRLCIQEGLSGRKSRKQQQRLLRNMGAHAVVLELLQIPYEKGEDVRMQDNMKLAHQFLQNFCAGNQQNQTLLHKHINLFLNPGILEAITMQHIFMNNFQLCSEINDRVVQHFVHCIETHGRNVQYLKFLQTIVKAENKFIKKCQDIVMAELVNAGEDVLVFYNDRASFQTLVNMMRSERDRMDENSPLRYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEIKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFDNFLVDICSVCNNTSDRKHADNVLERYVTETVMSIVTTFFSSPFSDQSTSLQTRQPVFVQLLQAIFRVYHCYWLGSGQKGSVEACIKVLSDVAKSRAIAIPVDLDNQVNNLFVRSNNIVQRTAISWRLSVRNSHLSARRESVVTVSRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDSRKKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQILVSRYYGNFHRSSGRRDSLTSFGNGPLSPLGPHAGGEMCGKSGLSRGEMTLSEVQCHLDKEGASDLVIDLIMNTTSDRVFQESILLAIALLEGGNTTIQRSFFCRLTDDKNSEKFFRVFYDRMKSAQQEIKATVTVNTSDLGNKRRDEDNQDRDAPVRKKARDSTVSMTEDVKEQLIEASSATKKAFNSYRREADPEDHCSSTDGLPSAGAKNQEEKMSFVVVIMQPILRFLQLLCENHNRDLQNFLRNQNKKNNYNLVCETLQFLDCICGSTTGGLGLLGLYINEDNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIIIALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMKPKELVEVIKKAYLQGEVEFVDIKEEEDVRDEEEHDAASPRNVGHNIYILAHQLARHNKELSMMLKPGGGSGDGDEALEFYAKHTAQIEIVRQDRTMEEIVFPVPNICEFLTSESKLRVYYTTERDEQGSKINDFFLRAEDLFNEMNWQKKLRAEPVLYWCSRNMSVWSNISFKLALLMNLLVCFFYPLEGVHGGILEPHLSALLWMGFFAALVLVLLMPKPLGILALVAVTILRLIFSVGLEPTLFLLGAFNVCNKIIFLVSFVGNRGTFTRGYKAMVMDFEFLYHLLYLIICCLGVFGHVFFYSLLLFDLVYREETLLNVIKSVTRNGRSIVLTAVLALILVYLFSIVGYIFFKDDFILEVDRIANATQSKETIGASLTGEFLNTGLCQGGLNENCSNSAQQEEFGIDGEDENDMERTCDSLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEVLKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLYFIVLVKVKDSTEYTGPESYVAEMIKEHNLDWFPRMRAMSLVSSDSEGEQNEIRNLQEKLESTMRLVINLSGQLTELKEQMTEQRKQKQRLGLLGHPPHLNINPQQPA","proteome":"UP000002852","gene":null,"go_terms":[{"identifier":"GO:0005262","name":"calcium channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070588","name":"calcium ion transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006816","name":"calcium ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005220","name":"inositol 1,4,5-trisphosphate-gated calcium channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070679","name":"inositol 1,4,5 trisphosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005783","name":"endoplasmic reticulum","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"1ecff67481f873b8000dc8c160c0c1860335ec80","counters":{"domain_architectures":5364,"entries":25,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":5,"ssf":3,"smart":1,"profile":1,"panther":1,"prints":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":5364}}}