{"metadata":{"accession":"K9KZX9","id":"K9KZX9_OVICN","source_organism":{"taxId":"112261","scientificName":"Ovis canadensis nelsoni","fullName":"Ovis canadensis nelsoni (Desert bighorn sheep)"},"name":"Sex-determining region Y protein","description":["Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons"],"length":240,"sequence":"MNRTVQSYASAMFRVLKDDVYSPAVVQQQNTFAFGKTSSLCTDNHSANDQCERGENVRESSQNHVKRPMNAFIVWSRERRRKVALENPKLQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRKAKRPQKSLAADSSILCNQMDAETLHPFTYRDDCAKTTHSQMESQLSRSQSVIITNSLLQKEHHSSWTNLGHDRVTLASRISADFPFYQSLEPGLSCAYVQY","proteome":null,"gene":"SRY","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030238","name":"male sex determination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ba71805ac3750d134530e8b8d14e816f9d4dbece","counters":{"domain_architectures":54587,"entries":12,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"cdd":1,"pfam":1,"profile":1,"pirsf":1,"panther":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":54587}}}