{"metadata":{"accession":"K9INW6","id":"K9INW6_DESRO","source_organism":{"taxId":"9430","scientificName":"Desmodus rotundus","fullName":"Desmodus rotundus (Vampire bat)"},"name":"F-BAR domain only protein 2","description":["Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor"],"length":811,"sequence":"MVMAHFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDPASAVEGIKPRKRKTFGLPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPEANQNDTKENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNQNSSSEELTKSKPSAASNEKGTSDLLAWDPLFGPSLDSSSSASLTSLLSSARPTTPLSVGAIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDMTISFPSGIIKVFTSNPSPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPTASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSGVSEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDVELVGTGYRLSLVKKRFATGRYLADC","proteome":null,"gene":null,"go_terms":null,"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6257cc3dcb31ffcc7982c9dc25ccbba5ba3f819b","counters":{"domain_architectures":2944,"entries":18,"isoforms":0,"proteomes":0,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":2,"cdd":2,"ssf":1,"smart":1,"pfam":2,"panther":1,"interpro":7},"proteome":0,"taxonomy":1,"similar_proteins":2944}}}