{"metadata":{"accession":"K9IM85","id":"K9IM85_DESRO","source_organism":{"taxId":"9430","scientificName":"Desmodus rotundus","fullName":"Desmodus rotundus (Vampire bat)"},"name":"Diacylglycerol lipase-beta","description":["Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages"],"length":666,"sequence":"MPGMVLFGRRWAIASDDLVFPGLFELFLRVLWWIGILTLYIRHRGRLDCAGGVLLSSYLIVLIILLAVIICTVSAIVGVSMRGTICNPGPRKSMSKLLYVRLALFLPEMAWASLGAAWIAGSVQCDRIVVNGVIATVVVSWIIVLSTAVTIFIVFDPLGGKTAPHSSAGPNLPDSHESSQFLTGLRTAATSVWERRIKLLCCCIGKDDHTRVAFSSTAELLSTCFSDTDLVPSDIAAGLSLLHQQQDSIRNNQEPKEVISHSPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPFTGLCKIGGDCCRRRTPESDLVGGDQLHCHFGSILHTTGLQYRDFIHISFHDKVYELPFIVALDHRKEAVVVAVRGTMSLQDILTDLSAESETLDLEYDVQDSLAHKGISQAARYVYRRLVSDGILSQAFSVAPEYRLVVVGHSLGAGAAALLAFMLRSSYPHVRCYAFSPPRGLLSKSLHEYSKDFTVSLVLGKDVIPRLSVTNLEDLKRRILRVIAHCDQPKYKILLRGCWYELFGGSPDGLRTELDRGGCADLTQPLLGEQSLLTRSSPLQSPTKYPPLYPPGRIIHLEEEGTSGRFSCYTSQYTAKWAPESEFSKILIGPKMLTDHMPDILMRALDSVVSDRAVCVSCPAPGGFSADDRPTPL","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fc928dcef83934fc9f01d159aae73bf9e479b9f4","counters":{"domain_architectures":46337,"entries":8,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"pfam":1,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":46337}}}