{"metadata":{"accession":"K7G2Y8","id":"K7G2Y8_PELSI","source_organism":{"taxId":"13735","scientificName":"Pelodiscus sinensis","fullName":"Pelodiscus sinensis (Chinese softshell turtle)"},"name":"5-hydroxytryptamine receptor 6","description":["G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling"],"length":435,"sequence":"PSPGQGRNLSPAFPPPCPWGNSWVAAFLCFIILLTTLGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNQLYGRWVLEGEFCSIWYSFDVMCCSASILNLCVISLDRYLLIISPLKYKLRMTFCRAVWLIFATWTLAALASFLPIKMGWHELEFEIRPLNSTSHMEEDQCRLLVSLPYALIASCLTFFLPSMAISFTYCRILLAARKQAVQVASLTTNMASTFDEPLQQVPGAQSQAAGLGENRKFANKHSKKALKASLTLGILLGMFFVAWLPFFVTNVTQAVCDCVPAAFFDVLTWLGYCNSTMNPIIYPLFMRDFKRAMAKYLPCCRRSWEGRPSAISLSMRNSNSGPRLGLSLKNVLTLQGETDSGDSVIQMNEHLLLPACRDPHLESIPATGADSVNLFDLEHTDQELQINQLNTPMA","proteome":"UP000007267","gene":null,"go_terms":[{"identifier":"GO:0004993","name":"G protein-coupled serotonin receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prosite":1,"prints":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}