{"metadata":{"accession":"K7AD20","id":"K7AD20_PANTR","source_organism":{"taxId":"9598","scientificName":"Pan troglodytes","fullName":"Pan troglodytes (Chimpanzee)"},"name":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 2","description":["Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit"],"length":489,"sequence":"MESMFSSPAEAALQREAGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPLPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRATPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVPLPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAENSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG","proteome":"UP000002277","gene":"DPH2","go_terms":[{"identifier":"GO:0090560","name":"2-(3-amino-3-carboxypropyl)histidine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017183","name":"protein histidyl modification to diphthamide","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3a7bb4719785c490f9695451c41f9eb2b83c367f","counters":{"domain_architectures":10011,"entries":13,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ncbifam":2,"cathgene3d":2,"sfld":3,"panther":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":10011}}}