{"metadata":{"accession":"K4G0J8","id":"K4G0J8_CALMI","source_organism":{"taxId":"7868","scientificName":"Callorhinchus milii","fullName":"Callorhinchus milii (Ghost shark)"},"name":"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial","description":["Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A"],"length":463,"sequence":"MFARCRSVSRSLSRWAVTRRPGALQASGSLGRRALSGLSVGHRVVNNNRQFQENVSKFRIFHIRHFKTSAVFNDEVMTVNTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTAVQVPAPHAGVIEELLVPDGGKVEGGTPLFKLRKTQAGAAKPKAAEAPTAPQPAVTPPSAPAHSTGPIPTTMPPVPQVSTQPMDSKPVSAVKASAVPAGFSVEAPDAGLKGGRSEHKVKMNRMRLRIAQRLKESQNTCAMLTTFNEIDMSNIQEMRALHKETFLKKHNMKLGFMSAFVKAASFALQNQPVVNAVIDDSTKEIIYREYIDISVAVATPKGLVVPVIRNVEMMNFADIEKAINELGEKARKNELAVEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFQRPVAIQGKVEIRPMMYVALTYDHRLIDGREAVMFLRKVKAVVEDPRVLLLDI","proteome":"UP000314986","gene":"dlst","go_terms":[{"identifier":"GO:0016746","name":"acyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004149","name":"dihydrolipoyllysine-residue succinyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006099","name":"tricarboxylic acid cycle","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045252","name":"oxoglutarate dehydrogenase complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"696e27af6f82e2120b0f8a44f2233f48ae538bfa","counters":{"domain_architectures":7190,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"ssf":2,"cdd":1,"pfam":2,"panther":1,"ncbifam":2,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":7190}}}