{"metadata":{"accession":"K0V8G8","id":"K0V8G8_MYCFO","source_organism":{"taxId":"1214102","scientificName":"Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 = JCM 6387","fullName":"Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 = JCM 6387"},"name":"Bifunctional NAD(P)H-hydrate repair enzyme","description":["Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration","Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration","Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX"],"length":470,"sequence":"MRYYYSADAIRAAEAPLLASLPDGVLMGRAAYGLATAIATELKLRTGGVAGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPEKTHAKGLAAFRHAGGRVVSGIFAATDLVIDGVVGISGRGPLRANAAAVFEANTAPVVAVDIPSGLDVQTGAADGPHVHAVLTVTFGGLKPVHALGECGRVELVDIGLDLTPTDLAGLEAADVRKLWPIPGPHDDKYTQGVTGVVSGSATYPGAAVLSTGAAVAATSGMVRYAGSAGPQVLSHWPEVIAAPSPQDAGRVQAWVVGPGLGTDDTAKAALRFALESELPVIVDADGLTLLAADPGLLAGRTAPTVLTPHAGEFERLAGDPPGADRVAAARGLAERLGATVLLKGNVTVIAEPGATTYLNPAGQSWAATAGSGDVLSGIIGSLLAAGLPPGEAAAAAAFVHARAANLSASDPGPNPAPTSASRILAHVRAAIAAL","proteome":null,"gene":"nnrE","go_terms":[{"identifier":"GO:0016836","name":"hydro-lyase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0052855","name":"ADP-dependent NAD(P)H-hydrate dehydratase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2d3cc4a65e0d282cab6625d9174661852f47cd75","counters":{"domain_architectures":19697,"entries":22,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"pfam":2,"cdd":1,"hamap":2,"pirsf":1,"panther":1,"ncbifam":1,"prosite":2,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":19697}}}