{"metadata":{"accession":"J4UHQ8","id":"OPS6_BEAB2","source_organism":{"taxId":"655819","scientificName":"Beauveria bassiana (strain ARSEF 2860)","fullName":"Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)"},"name":"Glutathione S-transferase-like protein OpS6","description":["Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of the bibenzoquinone oosporein, a metabolite required for fungal virulence that acts by evading host immunity to facilitate fungal multiplication in insects (PubMed:26305932, PubMed:28193896). The non-reducing polyketide synthase OpS1 produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:26305932). Orsellinic acid is then hydroxylated to benzenetriol by the hydroxylase OpS4 (PubMed:26305932). The intermediate is oxidized either nonenzymatically to 5,5'-dideoxy-oosporein or enzymatically to benzenetetrol by the oxidoreductase OpS7 (PubMed:26305932). The latter is further dimerized to oosporein by the catalase OpS5 (PubMed:26305932). OpS6 probably functions en route for protecting cells against oxidative stress by scavenging any leaked free radical form of benzenetetrol by activating the thiol group of glutathione (PubMed:26305932)"],"length":218,"sequence":"MASLQPIKLYAHKKGPNPWKVALILEELGLPYETTYLEFPDAKVEPYISLNPNGKLPAIQDPNHSIELFESGAIIEYLIEQYDKDGKLSHESLQDKSLARAWLHLQMSAQAPVIGYKVWMGRTYDASQIVSANEFLTLEIKRVLGVLDKHLAKMGGPYLLGSKVSYADLAFVPHYMMLPLFVPDYDPATEYPHFAAWLAALKERPAVKKIAATKAALA","proteome":"UP000002762","gene":"OpS6","go_terms":null,"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3c8295a330c09bde936e9b1d621b2d95072ea793","counters":{"domain_architectures":15127,"entries":17,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":2,"profile":2,"pfam":2,"cdd":1,"panther":1,"sfld":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":15127}}}