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{
"metadata": {
"accession": "I6QL64",
"id": "I6QL64_9FLAV",
"source_organism": {
"taxId": "381707",
"scientificName": "HoBi-like pestivirus",
"fullName": "HoBi-like pestivirus"
},
"name": "Genome polyprotein",
"description": [
"Acts as a cofactor for the NS3 protease activity",
"Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation",
"Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors",
"Plays a role in the regulation of viral RNA replication"
],
"length": 3899,
"sequence": "MELLNFELLYKTYKQKPAGVQEPLYDKNGAVLFGEPSDIHPQSTLKLPHPRGEKEVIVGIRDLPRKGDCRSGNRLGPVSGLFVKPGPVFYQDYSGPVYHRAPLEQFKQAPMCETTKRIGRVTGSDGNLYHMYVCTDGCILVKTAKREGQDVLKWVYNVLDSPIWVASCSDEKAGAKPKEKSKPDRVQKGKMQISPKETEKDSKTKPPDATIVVEGVKYQVKKKGKVRGKNTQDGLYHNKNKPEQSRKKLEKALLAWAVLALVLWQPVGAENITQWNLKDNGTNGIQHTMFIRGVNRSLHGIWPSKICSGVPTHLATDAELKQIHGMMDASEKTNYTCCRLQRHEWNKHGWCNWYNIEPWIRLMNKTQANLTEGTPLKECAVTCRYDKDKEINIVTQARDRPTTLTGCKKGKRFSFAGEVIDGPCNFNISAEDMLYDEMGCTGVFQEMAQHIVDGTTNTIEGARQGAAKLTTWLGKQLGILGKKLEHKSKTWFGAHAATPYCNINKKIGYVWYTNNCTPACLPKNTRIVGPGKFDTNGDDGKILHEMGSHLSELAILALVVMSDFAPESASVLYLILHFSIPQAHEEVDQCDRNQLNLTVSLRTDEVVPSSVWNLGKWVCVRPPWWPYETATVLAFEEIGQVLKLILRALKDLTNMWNAASTTAFLVCLVKILRGQIVQGVIWLLLITGAQGDLSCKPEFQYAISETDEIDLTGPTGLTTRWFAYSERLHITDSSVDLTCVDGNFLVHRRCVRKRRYLATVHERALSTSVKFTLVANPQDIEDVQMGDDFEFGLCPCDATPVIRGKFNTTLLNGPAFQLVCPYGWTGTVECTVVSDSTLKTQVVKRFVRYKPFPHRKHCMDQMVEGEDLYKCLYGGNWTCIPGDRVLYQGGKVKDCKWCGFIFEEPSDLPHFPLGKCRLTNETGYRYVDDTTCNRDGVAITKQGTLRCKIGKVEVRVLALNKDLGPMPCKPSHVTQSEGPVSKTACTFNWTETLENKYFEPRDNYFQQYMLKGKYQYWFDLEATDHHQDYFAEFIVIIVVALLGGRYVLWLLIVYYVVTDQGARGQQMNPGEVVLIGDMITHDSIEVITYFLLLYLLIKDEPVKKWVLLIYHAITASPRKTIIVAVLMFSSLVRGDDGRATQGDGPDVWFYVVLAMVCILLMVKRDPTTIPAVVMITGVKTRQYVAWLELDVALSIVAAVVLIHTYISSYYKYKQWLQCVISLLAGFFIIRTLKAVGECQLPAITVPNVRPLPIVLIYLITTTLVAHQNLDLAGIFLSNAPIMLMVLTLWADILTLILILPTYELTKLYYIRRVKKDVERSWLGATNFTRVDSVYELDGSEEGVYLFPSRQCPGAKTGEILPVLRCVLISCISSYWQWIYLIYLVIELVYFMHRRVIEEIAGGTNALSRMIAGLIEMSWALDEEESKGLKKFFILSARLKNLIMKHKVRNETIRAWYEEEEIYGMPKVITLIKAASLSQSKHCILCTVCERRDWKGGSCPKCGRSGRPISCGMTLADFEEKHYKRIFIREGELDGPFRQEARGYLQYIARGQLFLRNLPILATKVKLLMVGNLGSEVGDLEHLGWVLRGPAVCKKIVSHEKCHTGIADKLTAFFGIMPRGTTPRAPVRFPTSLIKIRRGLETGWAYTHQGGISSVDHVTAGKDLLVCDSLGRTRVVCQSNNKMTDETEYGIKTDSGCPEGARCYVLNPEAQNIAGTRGAMVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNEESKPTKLMSGIQTVSKSTTDLTEMVKKIVAMNRGEFKQVTLATGAGKTTELPRSVIEEIGRHKRVLVLIPLRAAAESVYQYMKQKHPSIAFNLRIGEMKEGDMATGITYASYGYFCQMPQPKLRAAMVEYSYIFLDEYHCATPEQLAIIGKIHRFSENLRVVAMTATPAGSVTTTGQKHPIEEFIAPEVMKGEDLGSNFLDIAGLKIPTEEMKGNMLVFVPTRNMAVEVAKKLKAKGYNSGYYYSGEDPANLRVVTSQSPYVVVATNAIESGVTLPDLDVVVDTGLKCEKRVRISSKMPFIVTGLKRMAVTVGEQAQRRGRVGRVKPGRFYRSQETASGSKDYHYDLLQAQRYGIEDGINITKSFREMNYDWSLYEEDSLLITQLEVLNNLLISDDLPAAVKNIMARTDHPEPIQLAYNSYEVQVPVLFPKIRNGEVTNEYEAYSFLNARKLGEDVPAYIYATENEDLAVDLLGLDWPDPGSQQVNETGKALKQVSGLSTAENALLVALFSYVGYQALSKRHIPMVTDIYTIEDQRLEDTTHLQYAPNAIRTDGKETKLEELAVGDIERYLSTAKEYASRGVGFIKTQALKVNDSPKVKETMESVHQYVEKLLETLKESQEDIIKYGLWGCHTALYKSIAGRLGNETAFATLVIKWLAFGGESLPAHVKQAAVDLVVYYIINKPSFPGDTETQQEGRRFVASLLVSALATYTHKTWNYNNLAKVVEPALAYLPYASKALSLFVPTRLESVVILSTAIYKSYLAIRKGKSDGLMGTGLSAAMEMMSQNPVSVGIAVMLGVGAVAVHNAIESSEQKRTLLMKVFVKNFLDQAATDELVKENPEKIIMAMFEAVQTIGNPLRLIYHLYGIFYKKWEAKELAERTAGRNLFTLIMFEAVELLGVDNEGKIRTLSSNYVLELLTKFCGNINNKVRNLVLGWAPAPFSCDWTPHDDRIKLPHENYALVVTRCPCGYESRSRKMDTGEMVKLEEKGPFLCRNRPGRNYGNLRVTRYYDKDGAELKPVIKLEKQAELYYKGVTLRVDFSNGKSVVATDKWEVDHSTITRLEKGYTGAGYKGAYLGDRPNHEALVERKCATITRDKVQFIKMVKGCAFTYDLSLSNLKRLIELVHKNKLEEREIPQATVTTWLAYTFVNEDIGTIRPSFGERVLPESPSDPSLQPSVVINRAAAEITVIGEAEQMTTGVTPVELNDNQAGVAGVNELEIGVKRGQFPGPVSQGKSLEEAIEEKDGRPYVLILGSKHSTSNRVKTAKNVRVYKGDSMQEVRDLMREGKLLVVALREVSKDLLHLVDYKGTFLTREALEALSMGRPRPKEATRAEITRLLNPTGEDIEVPECFTASEPVFLDAHIKGGTYHLVGSIQQIKEKAKTLGATDSTKIIQGLGSRVYTMKLSSWIHQNTTKDNDLRPLFEELLLQCPPSGRQTKGHVVSAYQLAQGNWEPISCNVYMGTIPARRVKTHPYEAYLKLKDLLSEHKMRVETGFADLKDHNRWILRKVKHQGNLRTKHILNPGKLSEQLEREGRKHNVYNKQIGSIMTSIGIRMEKLPVVRAQTDTVSFHQAIRDKIDKEENAQSPDLHEKLWEVFDTLKVPELKGVYDEVSWEELEAGINRKGAAGFLEKKNIGEVLASEKNLVEEIVKDLKRGKKINYYETAIPKNEKRDVNDDWEAGDLVDEKKPRVIQYPDAKVRLAITKVMYKWVKQKPVVIPGYEGKTPLFQIFDKVKKEWDGFNDPVAVSFDTKAWDTQVTSRDLRLIGRIQKYYFKNRWHKFIDTLTEHMTEVPVITADGEVYIRKGQRGSGQPDTSAGNSMLNVLTMVYAFCESAGVPYRSFNRVARIHVCGDDGFLITERGLGLKFASKGAQILYESGKPQKILEGDKMKVAYRFEDIEFCSHTPIPVRWSDNSSGYMAGRNTATVLAKMATRLDSSGERGTAAYEKAVAFSFLLMYSWNPLIRRICLLTLSSKPEVDPSKQATYYYKGDPIGAYKEVVGHNLHDLKRVGFEKLASLNLSMSTLGIWTRHTSKRLLEDCVKVGKEEGNWLVNADRLVSSKTNKMYIPDEGHTLQGKYYEELRLIGPGGPVLRVGKDRYRLGPIVNVILRRLRVLLMAAVGERAVI",
"proteome": null,
"gene": null,
"go_terms": [
{
"identifier": "GO:0016032",
"name": "viral process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0019082",
"name": "viral protein processing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003968",
"name": "RNA-directed RNA polymerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0004197",
"name": "cysteine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0004252",
"name": "serine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016817",
"name": "hydrolase activity, acting on acid anhydrides",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0017111",
"name": "ribonucleoside triphosphate phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0070008",
"name": "serine-type exopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0033897",
"name": "ribonuclease T2 activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0004175",
"name": "endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0004386",
"name": "helicase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0039694",
"name": "viral RNA genome replication",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "7ef85da071b73d8965482204f965403e6e8c7fe7",
"counters": {
"domain_architectures": 529,
"entries": 53,
"isoforms": 0,
"proteomes": 0,
"sets": 5,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 6,
"pfam": 9,
"cathgene3d": 7,
"ssf": 3,
"smart": 2,
"cdd": 2,
"panther": 1,
"prints": 1,
"prosite": 1,
"interpro": 21
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 529
}
}
}
