{"metadata":{"accession":"I3X8N6","id":"I3X8N6_SINF2","source_organism":{"taxId":"1185652","scientificName":"Sinorhizobium fredii (strain USDA 257)","fullName":"Sinorhizobium fredii (strain USDA 257)"},"name":"Nitrogen regulatory protein P-II","description":["In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed"],"length":112,"sequence":"MKKIEAIIKPFKLDEVKEALQEVGLQGITVTEAKGFGRQKGHTELYRGAEYVVDFLPKVKVEVVLADENAEAVIEAIRNAAQTGRIGDGKIFVSNVEEVIRIRTGETGLDAI","proteome":null,"gene":"glnB1","go_terms":[{"identifier":"GO:0030234","name":"enzyme regulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006808","name":"regulation of nitrogen utilization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d8220377dbaba070bd97071aa55ce9e6a39bd20d","counters":{"domain_architectures":32412,"entries":15,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"profile":1,"ssf":1,"cathgene3d":1,"smart":1,"pirsf":1,"panther":1,"prints":1,"prosite":2,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":32412}}}