{"metadata":{"accession":"I3P6P6","id":"I3P6P6_9PAPI","source_organism":{"taxId":"1070417","scientificName":"Human papillomavirus 144","fullName":"Human papillomavirus 144"},"name":"Protein E7","description":["E7 protein has both transforming and trans-activating activities","Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)"],"length":99,"sequence":"MRGQEPTIRDIDLNLEELVLPVNLLSDEDEPPVDDASVAEEEQRLFRIDTSCANCETGIRVIIHSTDSGARRLFDLLLEELSFVCPGCARSAVRHGRSH","proteome":"UP000156843","gene":"E7","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"775889284a0d0bec2201f51c28688b33e858eeb5","counters":{"domain_architectures":2302,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"hamap":1,"pirsf":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":2302}}}