{"metadata":{"accession":"I3MIC5","id":"I3MIC5_ICTTR","source_organism":{"taxId":"43179","scientificName":"Ictidomys tridecemlineatus","fullName":"Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)"},"name":"Zinc finger CCCH-type with G patch domain-containing protein","description":["Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor"],"length":465,"sequence":"GAGLEAAEQADLRQLQADLRELIGLTEASLVSVRKSKLLAALDAEAAGVPAGPEMAPEGEAGPGPAEPGRADPDPDPDPGELSGAKVNAPYRSAWGTLEYHNAMVVGTEAAEDGSAGVRVLYLYPTHKSLKPCPFFLEGKCRFKDSCRFSHGQVVSVDELRPFQDPDLSLLQAGSTCLAKHQDGLWHPARILDVDNGYYTVKFDSLLLKEAVVEGDSILPPLRTEAAESSDSDSGDAVDSSYARVVESGTADTGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCAEILQKRTKRSHAGASRPPRCQGSGSGPGGRPPPRNVFDFLNEKLQSQAPGALEAGAGPPGRRSQDMYHASKSAKQALSLRLFQTEEKIVRTQRDIQGIQEALTRNAGRHSVAAAQLEEKLAGAQRQLGQLRAQEAGLQREQRKADTHRKMTEF","proteome":"UP000005215","gene":"ZGPAT","go_terms":[{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a956554feafcbf58694e4d10123da3e3d2b08047","counters":{"domain_architectures":372,"entries":14,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":2,"profile":2,"pfam":2,"cdd":1,"ssf":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":372}}}