{"metadata":{"accession":"I3M581","id":"I3M581_ICTTR","source_organism":{"taxId":"43179","scientificName":"Ictidomys tridecemlineatus","fullName":"Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)"},"name":"Pseudouridylate synthase 7 homolog","description":["Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types"],"length":668,"sequence":"MEMTEMTGMSLKRGCLSMEDDDSAAPTEEIKKQKVSECCLTKRPDGLQNDCLPNRENVPGPPEPVSAKRGKMTSDDQLEEEEEEEEDGLSEEGEEEEEAESFADMMKHGLTELDVGITKFVSSHQGFSGILKERYSDFVVHEIGKDGQISHLDDLSVPVDEEDPSEDVFTILTAEEKQQLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGRKYIVAYHAAGKKALAKVRTAADPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDDQVQQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPAAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDLVLKGATATYIEEEDVDNYSIHDVVMPLPGFDIIYPKHKISEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGKPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQMNTTWLR","proteome":"UP000005215","gene":"PUS7","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009982","name":"pseudouridine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001522","name":"pseudouridine synthesis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0009451","name":"RNA modification","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"92340a834e84be0e54d2d11d205e2b29695b4ee5","counters":{"domain_architectures":6555,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"profile":1,"pirsf":1,"panther":1,"pfam":1,"ncbifam":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":6555}}}