{"metadata":{"accession":"H9ZEM3","id":"H9ZEM3_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"3'-5' exoribonuclease HELZ2","description":["Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA"],"length":2649,"sequence":"MAVWEAEQLGGLQRGDLLTPPAPNGDGRTVPLGQPPGAQLYCPACLVTCHSQEAFENHCASSEHAQMVAFDQAVPWEHRSPPPGLSKFELCPKPDLCEYGDACTKAHSAQELQEWIQRRRAVELRGQAAWQDGLVPYQERLLAEYQRSSSEVLVLTETLDGVRVTCNQPLKYQAQERKTQYSWTFAVHSEEPLLHVALLKQEPGANFSLVAPGLPSGRLYARGERFRLPSSAADFQVGVSVQAASFGTFEQWVVFDFGRRPVLLRKLGLQLGQGRHPEPYSSLALGHPEEMERWHTGNRHVVPAVERTAEQTALMAKYKDPALALEFNRSGLASGPISPTNYRQRMHQFLYEEETAQQQLVAKLTLRGPVFLKTALQTPALNMLFAPPGALYAEVPVPPSLMPDTDQGFLLGRAVSTALVAPVPAPNNAVFEVRLEKRASSEQVLWLLLPARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDTLPEEQLVVPDLPTCALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGKRVPPLLIYGPFGTGKTYTLAMASLEVIRRPQAKVLICTHTNSAADIYIREYFHSHVSGGHPEATPLRVMYADRPPSHTDPVTLQYCCLTDDHQAFRPPTWAELARHRVVVTTTSQARELRVPVGFFSHILIDEAAQMLECEALTPLAYASRGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLYYQQETHEVARQSRLVFHENYRCTEAIVSFVSRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDISTTSWLNLAEIAQAVEKVQEAYNTWPSCWGVREQRHICVVSHGAQVGALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGAPAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRRWLPRGTRAGAAGNWEAAPEPAGDPAEEPATVVTATVKAEPGDEALSPASGDITATTAQTEAAAAPAGEAVKEDAAPGAWAVGAAAAAGLESTEPEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVARPESPRQARLYENLPPAALRKLLRAEPGRYRHCTFVQETFERASAIPLDDASSGPIPVRGRLDCGMAFTGDEVLVQLLSGDRAPEGRLRGRVLGVLKRRRQELAFVCRMDRWDPRIMVPINGSVTKIFVAELKDPSRVPVYGLRKGRLQRVGFERLTAEARHSRLFWVHIVLWRPGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDLAAITKALQKYQTELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPGQEPVPMLPASLCQDILSLLPGRDRLAISLFLTMEKASGQLKSLHFAPSVVRSDRQLSYEEAEQVIRQHPGAGRELPAHLDSVDACVVAACYFSRLLRRHRLQSDCFYEQPDEDSTLGFRAAHIMVKEYMIQFNRLVAEFLVGSERTRTVTPLRWQPAPHSQQLKALCEKHGERVPLSLHLSHHLRGSGGSTPNTQLHLLASLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRCTWGHRQQGGHYSLQVEWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSARDIDGLCQGFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAGSRCFRLQFPSNRETLPDPCPVPYSSLQLAEHPRALAGRPGMQLLWRRRVYSVQGSGPPLPLPGTVLDPHTWAVETALWKQLLVLVELQRWPEAAALIQEKGEASPQRGLVQVQRSRCGHFLEVARELGSGDTLQVQLGASLQHGFLVPNPQLWTVAPGFSLCLEHVERPGDCFLGHVYQAPRDRYRDVDEYACVWEPFCALESATGAVAENDAVTLQHLSVSWDVSRMPQGQLQGAFRLEAAFLEENCVDINLSCCYLCIRLEGLPAPTASPHPGPSSLGPGLSVDPGTYTWVAHGQTEDWDQERRADRQEAPRQVHLFIHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYDIPGSRHKLNPSQNRAVREALEKPLTVIQGPPGTGKTIVGLHIIFWFHKSNQEQVQPGGSPHGETQLGGPCILYCGPSNKSVDVLAELLLRRMELRPLRVYSEQAEASEFPVPRPGSRKLLRRNPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQSGEPFSREDLVLYKKVLWEARKFELDRHEVILCTCSCAASASLKTLDVRQILVDEAGMATEPETLIPLVRFPQAEKVVLLGDHKQLRPVVKNEWLQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSRLKTWQGLKRLPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTIEPQDVAVLTPYNAQASEISKALRREGITGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQSLVPAGQVRVCRRPTMPS","proteome":null,"gene":"PRIC285","go_terms":[{"identifier":"GO:0004386","name":"helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004540","name":"RNA nuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"99eb37237381e5126557e706d2e6ca9272e5bf42","counters":{"domain_architectures":681,"entries":24,"isoforms":0,"proteomes":0,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"cathgene3d":1,"cdd":3,"pfam":4,"smart":1,"panther":1,"prosite":1,"interpro":10},"proteome":0,"taxonomy":1,"similar_proteins":681}}}