{"metadata":{"accession":"H9Z8B6","id":"H9Z8B6_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"Hydroxymethylglutaryl-CoA lyase, mitochondrial","description":["Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism"],"length":325,"sequence":"MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL","proteome":"UP000006718","gene":"HMGCL","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016833","name":"oxo-acid-lyase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004419","name":"hydroxymethylglutaryl-CoA lyase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f61fb8529fe655c17382dbb668bec796bf330a5e","counters":{"domain_architectures":29611,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"profile":1,"cdd":1,"panther":1,"ncbifam":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":29611}}}