{"metadata":{"accession":"H9G6N5","id":"H9G6N5_ANOCA","source_organism":{"taxId":"28377","scientificName":"Anolis carolinensis","fullName":"Anolis carolinensis (Green anole)"},"name":"Peptidyl-prolyl cis-trans isomerase E","description":["Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins","Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity"],"length":301,"sequence":"MASTKRVLYVGGLAEEVDERVLHAAFIPFGDITDIQIPLDYETEKHRGFAFIEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENVEEEGAEPARSEAQEGEPPAKKSRANPQVYMDIKIGNKPAGRLNILLRSDIVPMTTENFRCLCTHEKGFGFKGSSFHRVIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNSSQFFLTCDKTDWLDGKHVVFGEVTEGMDVVRKMEAQGTKDGKPKEKIIISDCGEYM","proteome":"UP000001646","gene":"ppie","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003755","name":"peptidyl-prolyl cis-trans isomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000413","name":"protein peptidyl-prolyl isomerization","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006457","name":"protein folding","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b9b36787d9478c52c1d0463c9f8611e5e36c3a8b","counters":{"domain_architectures":1756,"entries":23,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"smart":1,"pfam":2,"cdd":2,"pirsf":1,"panther":1,"prints":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1756}}}