{"metadata":{"accession":"H3CZP2","id":"H3CZP2_TETNG","source_organism":{"taxId":"99883","scientificName":"Tetraodon nigroviridis","fullName":"Tetraodon nigroviridis (Spotted green pufferfish)"},"name":"alcohol dehydrogenase (NADP(+))","description":["Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme. Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione. Displays no reductase activity towards retinoids"],"length":322,"sequence":"MNAFAVLSTGRKIPLLGLGTWKSDPGKVKQAVIWALQAGYRHIDCAAIYDNEAEIGEALQETVGPGKAIRREDVFITSKLWNTKHHPEDVEALLNTLKDLRLEYLDLYIHWPYAFRQGDVPFPKKEDGSLLYDNIDYKLTWAAMEKLVEKGLVRSIGLSNFNSCQIDDILSVASIKPTVLQVESHPYLAQVELLGHCRDRGLVMTAYSPLGSPDRAWKHPDEPVVLQEPVVLGLAEKYKKSPAQIVLRWQIQRGVVTIPKSVTESRIMENIQVFDFILEEEEMKTITSLNRGWRYILPTIKVDGQSVPRDAGHPYYPFNEPF","proteome":"UP000007303","gene":null,"go_terms":[{"identifier":"GO:0008106","name":"alcohol dehydrogenase (NADP+) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046185","name":"aldehyde catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e96b765c85e65c75beacfc1efe2818f689e0515d","counters":{"domain_architectures":291149,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"pfam":1,"pirsf":1,"panther":1,"prosite":3,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":291149}}}