{"metadata":{"accession":"H3BCE8","id":"H3BCE8_LATCH","source_organism":{"taxId":"7897","scientificName":"Latimeria chalumnae","fullName":"Latimeria chalumnae (Coelacanth)"},"name":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3","description":["Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron"],"length":290,"sequence":"MEDKRQRVRVQGSWAGPAKRTVLPHSASRTVGSRSHSTAAGPGWVKKESSVPEKQFVFDASSEVQKIACAVQYIPSFCRGNGTYEISTGATGVSRLQLLGNFIEPKEADWMFEQLRLEIPWKQETHVRQGVSYLEPRLTAWYGDLPYSYSRIRKEPNPHWHPLLSMLKDRIEEVTGYTFNSLLCNLYRNGKDSVDWHSDNEPSLSVNPVIASLSFGDTRVFEMRKKPAPEKNGDFTYVDRLKVPLDHGTLLIMEGATQEDWQHRVPKEYHDRGARINLTFRTIFPEPAKR","proteome":"UP000008672","gene":"ALKBH3","go_terms":[{"identifier":"GO:0051213","name":"dioxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006307","name":"DNA alkylation repair","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"908257cfaf43043a948bb4fa05b887e692b331c6","counters":{"domain_architectures":35525,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"profile":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":35525}}}