{"metadata":{"accession":"H2NMT9","id":"H2NMT9_PONAB","source_organism":{"taxId":"9601","scientificName":"Pongo abelii","fullName":"Pongo abelii (Sumatran orangutan)"},"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase","description":["The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses"],"length":1170,"sequence":"MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKVWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDPGGEAEGSSPPSAPAGERTVWAGEDGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYVPGAWADLTVALANPIKFFSAHDKKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPEPRTASLEELRELKAVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINNSHIQEVVQVIKQMTENLEGHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLVAKADAQESRL","proteome":"UP000001595","gene":"PLCB2","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004629","name":"C-type glycerophospholipase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016042","name":"lipid catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0c67981c2cb5936a0a344275925573d927a3144f","counters":{"domain_architectures":2564,"entries":43,"isoforms":0,"proteomes":1,"sets":8,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":5,"pfam":6,"cdd":4,"smart":3,"profile":3,"pirsf":1,"panther":1,"prints":1,"interpro":14},"proteome":1,"taxonomy":1,"similar_proteins":2564}}}