{"metadata":{"accession":"H2CMX6","id":"H2CMX6_LEPCL","source_organism":{"taxId":"48087","scientificName":"Lepus californicus","fullName":"Lepus californicus (Black-tailed jackrabbit)"},"name":"Atypical chemokine receptor 1","description":["Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels"],"length":291,"sequence":"SYNENESFDYNADLEAAAPCHSCNLLDDSSLPFFILASVLGILASGAVLFALLRPLFHWQLCPGRPILAQLAVGSALFSIVVPILAPGLSSAHSIILCGLGYWVWYGSAFAQALLIGCRACLGPKLGAGQSPXLTLGLTVGIWVAAALLGLPITLASDTSRGLCTLASSRGLGALQSTHAVACFVVFILWPLGLMGAKGLRKALGWGPGPWVDILWVWFIFWWPHGIFLGLDTLVRFRIILLPTCLVQKVLDLLLHLAEALAILHCVATPLLLALFCHQATRSSLPSLPLA","proteome":null,"gene":"DARC","go_terms":[{"identifier":"GO:0019956","name":"chemokine binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006954","name":"inflammatory response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070098","name":"chemokine-mediated signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":false,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":4,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"panther":1,"prints":1,"interpro":1},"proteome":0,"taxonomy":1}}}