{"metadata":{"accession":"H1VZX9","id":"NIS1_COLHI","source_organism":{"taxId":"759273","scientificName":"Colletotrichum higginsianum (strain IMI 349063)","fullName":"Colletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus)"},"name":"Necrosis-inducing secreted protein 1","description":["Secreted effector that induces necrotic lesions in Nicotiana benthamiana (PubMed:22352720). Interacts with the host receptor-like kinases (RLKs) BAK1/SERK3 and BKK1/SERK4, inhibits their kinase activity and suppresses INF1-induced pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) in N.benthamiana (PubMed:30584105). Also interacts with the host receptor-like cytoplasmic kinase (RLCK) BIK1 and inhibits its kinase activity, thereby inhibiting PAMP-induced ROS generation (Probable). In PTI, phosphorylation relaying by RLKs and RLCKs is critical for the initiation of downstream signaling (Probable)"],"length":144,"sequence":"MQFRASIAAAAGLFALANARIYGIAFPETVKAGDEVEAVITTENYIQAVQDIAIAFGIATEASAYPETLGNALGSFYLGPEESNTLENITETVTIPAGLAPGQYVVAAGLYSLYGASSSPTLSHYNVTVTVGNVTSETYVGSQR","proteome":"UP000092177","gene":"NIS1","go_terms":null,"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"599146f038d77204355a29940b82f9c77368fa06","counters":{"domain_architectures":1666,"entries":2,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":1666}}}