{"metadata":{"accession":"H0WNB2","id":"H0WNB2_OTOGA","source_organism":{"taxId":"30611","scientificName":"Otolemur garnettii","fullName":"Otolemur garnettii (Small-eared galago)"},"name":"NF-kappa-B inhibitor alpha","description":["Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription"],"length":314,"sequence":"MFQPVEHAPEWAMEGARDGLKKERLLDDRHDSGLDSMKDEDYEQMVRELREIRLEPQEAPRGAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITKQPEIAEALLEAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQTCTSQHLHSILQATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLKL","proteome":"UP000005225","gene":"NFKBIA","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"213489c9c2487618f3f125634eb87cb17253af2b","counters":{"domain_architectures":1108,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"pfam":2,"profile":2,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1108}}}