{"metadata":{"accession":"H0UTS6","id":"H0UTS6_CAVPO","source_organism":{"taxId":"10141","scientificName":"Cavia porcellus","fullName":"Cavia porcellus (Guinea pig)"},"name":"Ubiquitin thioesterase OTU","description":["Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin","Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation"],"length":348,"sequence":"MFGSSKGGHFGVHPQAGYPGGVSHPGSGAKAGPTGVWPAGDRTDTMWRLRCKAKDGTHVLQGLSSRTRLRELQGQIAAITGIAPGGQRILVGFPPECLDLSNGETVLGDLPIQSGDMLIVEEDQTRPRTPSAFTNHGAPSYVREPLPVLSRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNEEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYSKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSCNDDIVLVQALELADEARRKRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV","proteome":"UP000005447","gene":"YOD1","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8f10221ea8d0066fbf91fe68ded5298a9efae5d3","counters":{"domain_architectures":1982,"entries":18,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cdd":2,"cathgene3d":2,"pfam":3,"profile":1,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1982}}}