{"metadata":{"accession":"G7MQA4","id":"G7MQA4_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"JNK pathway associated phosphatase","description":["Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Activates the JNK signaling pathway. Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2. Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2. Dephosphorylates and thereby inactivates tyrosine kinase LCK. Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK. May play a role in B-cell receptor (BCR) signaling and B-cell function"],"length":198,"sequence":"ILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLREEYGESPLQDAEEAKSILGKYKEQGRVEPQPGARRWSSFPALAPLAYDNYTTET","proteome":null,"gene":"EGK_14403","go_terms":[{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"15742d355813370d995348f784781e84405a14d7","counters":{"domain_architectures":53529,"entries":13,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":1,"ssf":1,"profile":2,"cdd":1,"cathgene3d":1,"pfam":1,"panther":1,"prints":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":53529}}}