{"metadata":{"accession":"G5CB36","id":"G5CB36_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"Deoxycytidylate deaminase","description":["Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP)"],"length":180,"sequence":"PNVSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNAENKIVGIGYNGMPNGCSDDLLPWRRTAENKLDTKYPYVCHAELNAIMNKNSADVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDETTAARLMFEMAGVIFRKFTPRCNKIVIDFDSINSQPSQKLQ","proteome":null,"gene":"GW7_20027","go_terms":[{"identifier":"GO:0004132","name":"dCMP deaminase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006220","name":"pyrimidine nucleotide metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f99539802ad74cdae12e721eaf57a43643662eeb","counters":{"domain_architectures":85233,"entries":14,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"profile":1,"cdd":1,"ssf":1,"panther":1,"pirsf":1,"prosite":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":85233}}}