{"metadata":{"accession":"G5B4H1","id":"G5B4H1_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"Store-operated calcium entry-associated regulatory factor","description":["Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions"],"length":298,"sequence":"DRILLRDVKALTLHYDRYTTSRRLDPIPQLRCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYRFGKTVVSCEGYDSSEDQYVLRGSCGLEYHLDYTEIGLKKLKESGKQQGFSFSDFYYKIYSADSCATGGLVTIGILLTIAFVVYKLFLSDSQYSPPPYSEYPSYSQHYQRFTGSTGPSPPGFKSEFTGPQNTGRDAASGFGSAFAGQQGHENAGPGFWTGLGTGGILGYLFGSNRAATPFSDSWHHPSYPPPYASTWNSRAYSPPRGDLGGSSACSNSDTKTRTASG","proteome":null,"gene":"GW7_06291","go_terms":[{"identifier":"GO:2001256","name":"regulation of store-operated calcium entry","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005789","name":"endoplasmic reticulum membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d7370caaadf6922c1aee2c98c0eaf0bbc9ee50a5","counters":{"domain_architectures":2885,"entries":3,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"pfam":1,"interpro":1},"proteome":0,"taxonomy":1,"similar_proteins":2885}}}