{"metadata":{"accession":"G3WBG0","id":"G3WBG0_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Type 2 lactosamine alpha-2,3-sialyltransferase","description":["Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. It's alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes"],"length":329,"sequence":"MRGYLVFIILSCVFLYYVLHCILWRESTSWLRVMEMKRSPMLSCSLKPAFESLLSFRGIYPFMCTSDLKTIATLHESDKIALPYGVKKSVPDFHLALSRLQSCDLFPESDQLPCKKCIVVGNGAVLKNKTLGEKIDSYDVIIRINDGPVRGHEEDVGTKTTFRIFYPESVFTNPEDSDPESVAILAVFKPHDLKWLWELLSGITPVDHFWKKPALNLIYKPEKIRILDPIITRIAAFNMLHFPTTFPKKEKPKHPTTGIIAITLAFYICHEVHLAGFKYNFTDKDGPLHYYGNTTMSFMSKNEYHNITAEQIFLKNIIEKNFVINLTKD","proteome":"UP000007648","gene":"ST3GAL6","go_terms":[{"identifier":"GO:0008373","name":"sialyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009101","name":"glycoprotein biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"539ba3211ecb1f85127c965aa98c3308f6899026","counters":{"domain_architectures":29312,"entries":8,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pirsf":1,"panther":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":29312}}}