{"metadata":{"accession":"G3W8S2","id":"G3W8S2_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Serine/threonine-protein kinase receptor","description":["On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6"],"length":505,"sequence":"MEFEFRRATSCAILGRSETQECIFYNANWEKDRTNRTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRNDCIEKKDNPEVYFCCCEGNMCNERFFYFPEMEITIPTSNPVTPKPPLFSTLLYSLVPIMLIAGIVLLSFWMYRHHKLAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIIQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL","proteome":"UP000007648","gene":"ACVR2A","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004675","name":"transmembrane receptor protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007178","name":"cell surface receptor protein serine/threonine kinase signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726173b0dde7bbc50c5d845a39c992d18faf18f3","counters":{"domain_architectures":887312,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"cdd":2,"ssf":2,"smart":1,"profile":1,"pfam":1,"panther":1,"prints":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":887312}}}