{"metadata":{"accession":"G3UMP0","id":"G3UMP0_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Alpha-1B adrenergic receptor","description":["This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes"],"length":508,"sequence":"MNPNLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSAALEILGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDPLSSSKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVVWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRLGGGAYTYRPWTRGCSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFAEWKAPGALLSLPAPEPLGRRGRQDSGPLFTFRLLAEPESPETDGGASNGGCDAAADVANGQPGFKPNMPLAPGHF","proteome":"UP000007646","gene":"ADRA1B","go_terms":[{"identifier":"GO:0004937","name":"alpha1-adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006937","name":"regulation of muscle contraction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019229","name":"regulation of vasoconstriction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0055117","name":"regulation of cardiac muscle contraction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004935","name":"adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"smart":1,"profile":1,"pfam":1,"panther":1,"prints":3,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}