{"metadata":{"accession":"G3UHM6","id":"G3UHM6_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"TIR domain-containing adapter molecule 1","description":["Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines"],"length":700,"sequence":"MADTEPSLPGAFDILRGAGQDKLLHLKHKLKTLHLSCQGASLLRAMVLLALGQDTEARLSLEMLRTDAAAQFVARRWASMDITEALEEPKDMSWTVACVYHLLAEEKLCPASLREAAYRAALQALSSMDDPRLPELQAEARDRCGWDVSNSGGFQPLHSHLGGRPPSSALRSEIRSVPQPIRNPSGWSQACSLKSTDSPASLASNLEISQSPTMLFLTQPHSPPRPSKLCDEPRDSLRPEPTPMGCQEPEQVNWPPSMETDPPQEPPHSPAPQLPVVAPDPSPAGLPNPSTPLASRAHYPEECTEVSVAPQSLPSTPQSLPSPVLDPPDNPTKNGTSVPLSVEDTASQKSKQSPPPPSAPQTSSPSHSASASPACAAPPASSSGPAPPELESSEQKFYNFVVLHARADEHVALRVRERLEQLGVPDGATFCEDFRVPGRGELSCLQDAIDHSAFTILLLTPNFDCRLSLHQVTQALMSSFVRHGWQDSVIPFQPLETSELSSDATRLLSSLVCLNEHSQLFERKVKNTFKRQKLQERKATWKKEQQVRAVREYSQHLEGERQHAAEMSTAYSAYLQSYLAFQAQMERLQVALGTQMSLGPQMPPGVQMPFAGQVPQGVQLPLPTWPGYPQPPLPPWLASTPPPAFPQPPSFLPVSPGSPQSPGLQPLIIHHAQMVQLGLNNHMWGQREAQAPEDKSQEAE","proteome":"UP000007646","gene":"TICAM1","go_terms":[{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035666","name":"TRIF-dependent toll-like receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"49eb82fa59e72e6d993b097b734c38c0b130d4c2","counters":{"domain_architectures":228,"entries":12,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"ssf":1,"profile":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":228}}}